Paradigm4: 1 Billion Regressions in an Hour- Unlocking the Promise of the UK BioBank

July 16, 2020

Alnylam Pharmaceuticals and Paradigm4 partnered to uncover genetic and metabolic drivers of disease based on UK BioBank's unprecedented data set (1.5PB+ of multi-modal, longitudinal data shared by 500,000 UK citizens, including genomic, clinical, self-reported, behavioral, imaging and biometric information). Paradigm4’s scientific computing platform streamlined creation of custom phenotypes across all data modalities, provided rapid access to precise cohorts, and ran computationally intensive genome/phenome association algorithms (GWAS)—with 1 billion linear regressions in an hour—using thousands of spot CPU cores at the push of a button. The collaboration enabled Alnylam to establish a human genetics program in less than a year, publish multiple significant results, and optimize cloud cost/performance.

Presented by Alex Poliakov, V.P. Customer Solutions, Paradigm4
and Greg Hinkle,V.P Research Informatics, Alnylam Pharmaceuticals

Previous Video
Benchling: The Next Digital Transformation of Life Sciences R&D
Benchling: The Next Digital Transformation of Life Sciences R&D

Presented by Rashi Takkar, Product Marketing Manager, Benchling

Next Video
Deloitte: MyPath for Clinical- Enabling Decentralized Clinical Trials
Deloitte: MyPath for Clinical- Enabling Decentralized Clinical Trials

Presented by Chris Zant- Chief Digital Officer; Dawn Anderson- Managing Director; and Ryan Hoffmeister- Chi...